|
ANLL |
acute
nonlymphoblastic leukemia |
|
AO |
aldehyde
oxidase |
|
AUC |
area
under the curve |
|
BBBD |
blood
brain barrier disruption |
|
CL |
systemic
clearance |
|
CSF |
cerebrospinal
fluid |
|
Css |
steady
tate concentration |
|
DAMPA |
2,4-diamino-N10-methypteroic
acid |
|
DHFR |
dihydrofolate
reductase |
|
ECF |
extracellular
fluid |
|
fb |
free
fraction |
|
F-MTX |
fluoresceinated
methotrexate |
|
g |
gram |
|
Glu |
glutamic
acid |
|
h |
hour |
|
IL |
interleukine |
|
INF-gamma |
interferon-gamma |
|
i.p. |
intraperitoneally |
|
i.v. |
intravenously |
|
kg |
kilogram |
|
LD50 |
dose
causing lethality in 50% of the population |
|
MCDB402 |
molecular,
cellular and developmental biology medium 402 |
|
mg |
milligram |
|
MRT |
mean
residence time |
|
7-OH-MTX |
7-hydroxymethotrexate |
|
p.o. |
per
os / orally |
|
RSA |
röntgen
stereophotogrammetric analysis |
|
SCE |
sister
chromatid exchange |
|
SLE |
systemic
lupus erythematosus |
|
t1/2α |
halflife
of distribution |
|
t1/2β |
halflife
of elimination |
|
TFI |
tubular
fertility index |
|
TNF |
tumor
necrosis factor |
|
U-ARF |
uranyl
nitrate induced acute renal failure |
|
UNX |
unilaterally
nephrectomised |
|
Vd |
volume
of distribution |